学校简介

不列颠哥伦比亚大学（University of British Columbia，又译“英属哥伦比亚大学”等），简称UBC，位于加拿大温哥华市，始建于1908年，是一所公立大学。该校前身为麦吉尔大学不列颠哥伦比亚分校（McGill University College of British Columbia），于1915年获批独立。温哥华校区，位于加拿大第三大城市温哥华的市郊，距离温哥华只有30分钟的车程，校区占地达400公顷。这里有怡人的气候，绵延的海岸线，美丽的海洋与沙滩，是游览观光者必到之处。此外，温哥华校区还有该市最吸引人的许多学术及休闲娱乐设施，包括人类学博物馆、表演艺术中心、著名的UBC植物园及植物研究中心等。温哥华校区是UBC最大的校区，学生人数超过45,000名。不列颠哥伦比亚大学2024QS排名34。

招聘职位

招聘职位：博士后研究员（里德实验室）

学院：医学院

部门：小儿科

全职：全职

该职位位于医疗机构内。因此，该职位需要根据省级卫生授权的要求，成功验证在开始日期之前提供的针对 Covid-19 的完全疫苗接种。

职位摘要：

位于加拿大温哥华的不列颠哥伦比亚大学附属不列颠哥伦比亚省儿童医院研究所提供复杂流式细胞术的博士后职位。与Reid研究团队合作，成功的申请人将领导一个行业赞助项目的开发，以评估产生抗体的细胞培养物中的B细胞成熟，并为正在进行的化疗和小儿白血病后患者的免疫重建研究做出贡献。

Job title: Postdoctoral Fellow (Reid Lab)

Faculty: Medicine

Department: Pediatrics

FTE: Full time

This position is located within a health-care facility. Therefore, this position requires successful verification of full vaccination against Covid-19 provided prior to the start date, as required by the provincial health mandate.

Job Summary:

A postdoctoral position in complex flow cytometry is available at The University of British Columbia-affiliated BC Children’s Hospital Research Institute in Vancouver, Canada. Working with the Reid research team , the successful applicant will lead the development of an industry-sponsored project to evaluate B cell maturation in antibody-producing cell cultures, and contribute to ongoing studies of immune reconstitution in patients after chemotherapy and pediatric leukemia.

资格和责任

工作内容：

-设计和实施研究计划，研究体外B细胞成熟和儿童癌症免疫学。

-进行流式细胞术实验和分析。保持最新的流式细胞仪技术，方法和软件分析程序。

-促进研究合作，并与学术，临床，行业和其他合作伙伴共同工作。

-科学地记录实验室实验，数据分析，解释-参与拨款准备，撰写手稿并在内部和外部会议上展示结果。

-指导实验室的初级学员。

资格要求:

我们正在寻找一名独立的个人，他在过去两年内完成了分子或细胞生物学，免疫学或相关学科的博士学位，他在流式细胞术数据采集和分析方面表现出专业知识。

-具有丰富的多色流式细胞术背景，包括复杂面板设计，标记物选择，检测开发(>10颜色)。

-在免疫学，干细胞发育和/或血液恶性肿瘤背景下具有复杂的基于流量的数据门控经验。

-深入了解基于流动的群体特征，免疫细胞亚群复杂性和罕见事件检测。

-在复杂数据采集方面的技术专长，确保流量数据采集的标准化和稳健性，运行宝贵的样品。

-熟练掌握FlowJo等分析软件(Kaluza, Infinicyt等)，具有基于算法的高维流分析经验。

-具备在复杂研究数据集中探索、理解和分析新模式的能力。

-较强的数据可视化，统计分析和研究成果的表达/写作能力。

-优秀的沟通能力，注重细节，能够在跨学科研究环境中工作。

-对人类造血、肿瘤免疫学、癌症/白血病生物学有深入了解。

-有计算(R-based)分析复杂流量/组学数据集和/或光谱流式细胞术经验者优先。

Work Performed:

-Design and implement research plans to investigate in vitro B cell maturation and the immunology of pediatric cancers.

-Conduct flow cytometry experiments and analyses. Keep up-to-date on new flow cytometer technologies, methodologies and software analyses programs.

-Foster research collaborations and work jointly with academic, clinical, industry, and other partners.

-Scientifically document lab experiments, data analysis, interpretations.

-Contribute to grant preparation, write manuscripts and present results at internal and external meetings.

-Mentor junior trainees in the laboratory.

Qualifications:

We are looking for an independent individual who has completed their PhD in the field of molecular or cellular biology, immunology or a related discipline within the last two years, who has demonstrated expertise in flow cytometry data acquisition and analysis. The ideal candidate should possess:

-Strong background in multicolour flow cytometry, including complex panel design, marker selection, assay development (> 10 colours).

-Significant experience with complex gating of flow-based data in immunological, stem cell development, and/or hematological malignancy context.

-In-depth understanding of flow-based population characteristics, immune cell subset complexity and rare event detection.

-Technical expertise in complex data acquisition, in ensuring standardization and robustness of flow data acquisition, running precious samples.

-Expert knowledge of FlowJo, other analysis software (Kaluza, Infinicyt, etc.), including proven experience with algorithm-based high-dimensional flow analysis.

-Demonstrated ability to explore, understand and analyze novel patterns in complex research datasets.

-Strong data visualization, statistical analysis and presentation/writing skills of research findings.

-Excellent communication, attention to detail and commitment to work in an inter-disciplinary research environment.

-Advanced understanding of human hematopoiesis, tumour immunology, cancer/leukemia biology.

-Additional experience in computational (R-based) analysis of complex flow/omics datasets, and/or spectral flow cytometry would be an asset.

申请方式

如申请此职位，请发邮件至邮箱，并附上以下内容。

◆ 当前简历

◆ 求职信

截止时间：2023年11月30日

To apply for this position, please email with the following items attached.

◆Current CV

◆Cover letter