院校简介

芝加哥大学（The University of Chicago，简称UChicago、“芝大”）由石油大王约翰·洛克菲勒于1890年创办，坐落于美国金融中心芝加哥，一所私立研究型大学，全球大学校长论坛成员，入选英国政府“高潜力人才签证计划”。2021-22年度，芝加哥大学位列U.S. News美国最佳大学排名第6、软科世界大学学术排名第10、泰晤士高等教育世界大学排名第10、QS世界大学排名第10、U.S. News世界大学排名第15。

实验室介绍

芝加哥大学周氏实验室正在寻找一名对化学生物学和蛋白质/抗体工程方法的靶向免疫疗法发展有浓厚兴趣的博士后研究员。

我们在化学和生物学充满活力的界面工作，特别关注肿瘤微环境(TME)内细胞表面的复杂动力学。这个跨学科的职位为寻求在蛋白质/抗体工程和免疫治疗领域做出重大贡献的博士研究生提供了一个极好的机会。

该职位提供了在芝加哥大学放射与细胞肿瘤学系和化学系充满活力和协作的环境中工作的机会。

您将与周博士密切合作，他在肽化学、化学生物学、蛋白质/抗体/细胞工程和免疫治疗方面拥有丰富的经验和培训。

周实验室也是芝加哥大学综合癌症中心的一部分，为合作研究和职业发展提供了额外的机会。

The Zhou Lab at the University of Chicago is seeking an enthusiastic and dedicated Postdoctoral Researcher with a strong interest in the development of targeted immunotherapies with chemical biology and protein/antibody engineering approaches. 

We work at the vibrant interface of chemistry and biology, with a specific focus on the complex dynamics of cell surfaces within the tumor microenvironment (TME). This interdisciplinary position presents an excellent opportunity for a Ph.D. graduate seeking to make significant contributions to the field of protein/antibody engineering & immunotherapy. 

This position offers an opportunity to work in a dynamic, collaborative environment within the Department of Radiation & Cellular Oncology and the Department of Chemistry at the University of Chicago. 

You'll work closely with Dr. Zhou, who has extensive experience and training in peptide chemistry, chemical biology, protein/antibody/cell engineering, and immunotherapy. 

The Zhou Lab is also part of the University of Chicago Comprehensive Cancer Center, offering additional opportunities for collaborative research and career development. 

项目和技术

成功的候选人将成为我们正在进行的研究项目的一部分，重点是:

•阐明新的化学和生物现象或机制的细胞膜贡献病理表型。

•利用这些见解来推动下一代免疫疗法的发展。

•设计小分子和生物制剂，以增强我们对疾病的理解，并促进创新疗法的创造。

潜在的候选人将采用多种方法/技术，包括合成化学，蛋白质组学，功能基因组学和蛋白质/抗体/细胞工程。他们还将利用噬菌体/酵母/细胞/病毒展示等组合选择技术，结合下一代测序(NGS)和生物信息学，推进生物学研究。

The successful candidate will be integral to our ongoing research projects, with a focus on:

• Elucidating new chemical and biological phenomena or mechanisms on cell membranes contributing to pathological phenotypes.

• Harnessing these insights to drive the development of next-generation immunotherapies.

• Engineering small molecules and biologics to enhance our understanding of diseases and facilitate the creation of innovative therapeutics.

The potential candidate will employ a diverse range of methodologies/technologies, including synthetic chemistry, proteomics, functional genomics, and protein/antibody/cell engineering. They will also leverage combinatorial selection technologies such as phage/yeast/cell/virus display, coupled with next-generation sequencing (NGS) and bioinformatics, to advance biological research.

资格

被选中的个人被期望能够熟练地管理多个相互竞争的项目，并保持全面和清晰的研究笔记。

成功的候选人应该能够在内部小组会议和外部科学研讨会上向芝加哥大学内外更广泛的科学界展示他们的研究进展。我们正在寻找高度独立，足智多谋，并对癌症免疫治疗充满热情的候选人。

具有博士学位或同等学历，化学、化学生物学或生物化学博士优先。有有机化学背景或有分子生物学实验经验，如克隆、蛋白表达和纯化。了解基本的免疫学概念。具有组合选择技术，下一代测序(NGS)和生物信息学方面的经验。能够用英语书写和表达清晰完整的研究成果。具有独立工作和团队合作的能力。

The selected individual is expected to proficiently manage multiple and competing projects and to maintain comprehensive and clear research notes. 

The successful candidate should be capable of presenting their research progress in internal group meetings and external scientific seminars to the broader scientific community within and outside the University of Chicago. We are seeking candidates who are highly independent, resourceful, and passionate about pioneering cancer immunotherapies.

A Ph.D. or educational equivalent required Ph.D. in chemistry, chemical biology or biochemistry are preferred. Organic chemistry background OR experience of molecular biology experiments, such as cloning, protein expression and purification, is appreciated. Knowledge of basic immunological concepts is appreciated. Experience in combinatorial selection technologies, next-generation sequencing (NGS), and bioinformatics is highly desirable. Ability to write and verbalize clear and complete research findings in the English language. Demonstrated ability to work independently and as a team member.

报名方式

有意向的候选人应将2-3名推荐人的简历发送至以下邮箱:info@zhengzicn.com。

Motivated candidates should submit a CV with names of 2-3 referees to email：

info@zhengzicn.com