一、院校简介

牛津大学（University of Oxford），简称“牛津”（Oxford），位于英国牛津，是一所公立研究型大学，采用传统学院制。是罗素大学集团成员，被誉为“金三角名校”、“G5超级精英大学”，全球大学校长论坛成员。牛津大学的具体建校时间已不可考，但有档案明确记载的最早的授课时间为1096年，亨利二世在1167年禁止英国学生就读巴黎大学，因得到了英国王室的大力支持而快速发展。

牛津大学是英语世界中最古老的大学，也是世界上现存第二古老的高等教育机构。从1902年起，牛津大学还设立了面向全世界本科生的“罗德奖学金”。

2024QS世界大学排名发布，牛津大学位列第3名。

二、招聘职位

博士后研究科学家:研究心脏发育的细胞和分子机制

全日制，固定期限从2024年3月1日至2029年2月28日。

邀请博士后研究科学家与Paul Riley教授一起在bbsrc资助的合作项目上工作，作为剑桥大学研究人员联盟(CellTalkHDD)的一部分(Sanjay Sinha教授-联盟领导PI;Richard Tyser博士)，牛津大学(Filipa博士Simões)和Wellcome Trust Sanger研究所(Sarah Teichman博士)，研究人类心脏发育的细胞和分子机制。

整个联盟的目标是全面定义胚胎和胎儿人类心脏发育的细胞状态、细胞串扰和组织微环境。将人类发育心脏细胞图谱数据(由该项目和已发表的数据集生成)与现有的和新的hPSC衍生的体外模型相结合，以重建特定的发育小生境，并通过实验确定培养皿中细胞间串扰和小生境功能的关键分子调节剂。确定模型生物在多大程度上忠实地反映了人类心脏中的细胞和分子事件。我们将在动物模型中生成可比较的多基因组和空间数据集，并采用深度学习方法来定义保守生态位和信号事件，以进行功能测试。

Postdoctoral Research Scientist: investigating the cellular and molecular mechanisms of heart development

Full time, fixed term from 01st March 2024 until 28th February 2029.

Applications are invited for a Postdoctoral Research Scientist to work with Professor Paul Riley on a BBSRC-funded collaborative project as part of consortium (CellTalkHDD) of investigators from the University of Cambridge (Professor Sanjay Sinha- consortium lead PI; Dr Richard Tyser), University of Oxford (Dr Filipa Simões) and Wellcome Trust Sanger Institute (Dr Sarah Teichman), studying the cellular and molecular mechanisms of human heart development.

The overall consortium aims are to comprehensively define the cell states, cellular crosstalk and tissue microenvironments of embryonic and fetal human heart development. To combine human developmental heart cell atlas data (both generated by this project and published data sets) with existing and novel hPSC-derived in vitro models to recreate specific developmental niches and experimentally determine the critical molecular regulators of cell-cell crosstalk and niche function in the dish. To determine to what extent model organisms faithfully reflect cellular and molecular events in human hearts. We will generate comparable multiome and spatial datasets in animal models and employ deep learning approaches to define conserved niches and signalling events for functional testing.

 三、研究项目

这个项目将提供对动物模型心脏发育的比较研究。职责将包括整合现有的和新生成的多组数据集，包括空间转录组学，与人类和动物模型数据集，以确定细胞串扰和小生境生物学的保守调控。通过基因编辑和体内表型对保守生态位因子的功能评估。此外，成功的申请人将测试人类多能干细胞(hPSC)衍生的心血管细胞类型通过异种移植整合到正在发育的动物模型中的能力，因此该项目将结合验证动物模型和hPSC衍生物作为研究人类心脏发育的模型系统。

他们将被要求在实验室环境中使用专业的科学设备，并根据经验和成绩为实验室内其他正在进行的研究项目做出贡献。此外，他们将向研究生和本科生教授实验技术，并在实验室内对这些学生进行监督。成功的申请人将出席内部小组会议，并有机会参加外部科学会议，并为项目研究的出版起草文稿。通过大学内部和外部开设的课程，将有进一步研究培训的空间，例如计算生物学。

This project will provide comparative insights into animal model heart development. Responsibilities will include integrating existing and newly generated multiome datasets, including spatial transcriptomics, with human and animal model datasets to identify conserved regulators of cellular cross talk and niche biology. Functional assessment of conserved niche factors via gene editing and in vivo phenotyping. In addition, the successful applicant will test the ability of human pluripotent stem cell (hPSC)-derived cardiovascular cell types to integrate into the developing animal model through xenotransplantation, thus in combination this project will validate the animal model and hPSC-derivatives as model systems to study human heart development.

They will be required to use specialist scientific equipment in a laboratory environment, and to contribute to other on-going research projects within the laboratory, in accordance with experience and grade. In addition, they will teach experimental techniques to graduate and undergraduate project students and provide supervision of these students within the laboratory. The successful applicant will be expected to present at internal group meetings and will have the opportunity to attend external scientific meetings and to contribute to drafting manuscripts for the publication of the project studies. There will be scope for further research training through courses run both within the University and externally, for example in computational biology.

四、申请方式

成功的申请人将持有或即将完成相关的博士学位，并具有与工作计划相关的分子/细胞生物学方面的经验。他们必须有强烈的动机，对科学有高度的热情，有良好的组织、语言、交流和人际交往能力。他们必须既能独立工作，也能成为研究团队的一员。成功的申请人最好(但不是必须的)有动物模型心血管研究的经验。有组织学和基因/蛋白质表达分析经验，有图像分析软件的共聚焦显微镜经验者优先。

申请截止日期为2023年12月31日。

The successful applicant will hold, or be near to completion of a relevant PhD degree, and have experience in molecular/cellular biology relevant to the programme of work. They must be strongly motivated with a highly enthusiastic approach to science and good organizational, verbal, communication, and interpersonal skills. They must be able to work both independently and part of a research team. It is desirable (but not essential) that the successful applicant has experience in cardiovascular research working with animal models. Experience of histology and gene/protein expression analyses and confocal microscopy with image analysis software would be beneficial.

The application deadline is December 31, 2023.

联系方式

info@zhengzicn.com