一、院校简介

昆士兰大学位居澳大利亚的八大名校前列，连续多年被亚洲周刊评为亚太地区最好的大学之一。昆士兰大学商学院是澳洲仅六所获得AACSB认证的商学院之一，在澳大利亚政府对各大学就教学、研究、校园服务三项指标进行的质量评比中名列前茅。

昆士兰大学位于澳大利亚东部的海滨，以拥有强大的教学和科研力量而受到国际的赞誉。它颁发的学历资格证书获得全世界的公认，社会对这所大学的毕业生具有极大的需求量。它培养了无数优秀人才，许多在商界、政界的领导人物都是出自于昆士兰大学。

昆士兰大学位居2024QS世界大学排名第43位。

二、招聘职位

对于博士后研究员来说，这是一个令人兴奋的机会，他们可以集中精力发展他们在肽化学和离子通道生物学方面的专业知识和新兴研究概况。我们的实验室探索了节肢动物捕食者的毒液，以发现调节与人类疾病有关的离子通道活性的肽。该项目专注于在支配肠道的痛觉神经纤维中发现的靶向离子通道。该职位的候选人将参与项目的所有方面，并预计将有助于出版和申请有竞争力的研究资金。

主要职责包括:

研究

-合成、折叠和纯化富含二硫键的肽，包括含有非天然氨基酸残基的肽。

-开发肽结构-功能关系。

-针对一系列电压门控离子通道的肽活性的电生理学分析，包括肽效力和相互作用动力学的测量。

-哺乳动物细胞系的培养。

-在主要研究者的指导下设计和进行独立实验。

-编写研究出版物和进度报告。

-参加讨论项目目标、方法和结果的会议。

-保持项目的实验记录，同时展示自主性和个人主动性，以协助实验室组织和文件。

-通过在高质量渠道发表或展示，产生符合学科规范的高质量研究成果。

-参与申请竞争性研究资助。

-与同事和研究生合作开发跨学科联合研究项目。

This is an exciting opportunity for a Postdoctoral Research Fellow to focus their efforts on developing their expertise and emerging research profile in peptide chemistry and ion channel biology. Our laboratory explores the venoms of arthropod predators to discover peptides that modulate the activity ion channels involved in human disease.

This project focuses on targeting ion channels found in pain-sensing nerve fibres that innervate the gut. The candidate for this position will be involved in all aspects of the project and will be expected to contribute to publications and applications for competitive research funding.

Key responsibilities include:  

Research

-Synthesis, folding and purification of disulfide-rich peptides, including those with non-native amino acid residues.

-Development of peptide structure-function relationships.

-Electrophysiological analysis of peptide activity against a range of voltage-gated ion channels, including measurement of peptide potency and kinetics of interaction.

-Culture of mammalian cell lines.

-Design and conduct independent experiments under the guidance of the Principal Investigator.

-Preparation of research publications and progress reports. 

-Participation in meetings to discuss project objectives, methodology and outcomes.

-Maintain experimental record keeping of projects, whilst demonstrating autonomy and personal initiative to assist with laboratory organisation and documentation.

-Produce quality research outputs consistent with discipline norms by publishing or exhibiting in high-quality outlets.

-Participate in applications for competitive research funding support.

-Work with colleagues and postgraduates in the development of interdisciplinary joint research projects.

三、职位要求

关于您

-完成一个以肽化学或相关领域为重点的博士学位。

-学科领域研究的新兴轮廓。

-擅长微波辅助固相多肽合成富含二硫键的多肽。

-擅长富含二硫键的多肽的折叠和纯化，尤其是反相HPLC。

-开发肽结构-功能关系的经验。

-动物毒液的处理和高效液相色谱分离经验。

-擅长培养稳定的哺乳动物细胞系。

-精通自动膜片钳电生理学。

-最好有使用Sophion QPatch 16X系统的经验。

-深入了解电压门控钠通道的结构和功能。

-使用核磁共振波谱法测定肽三维结构的经验。

-在著名的参考期刊上发表论文以及在肽会议上发表论文的证据。

-致力于参与多样化、公平、包容和安全的研究实验室环境。

About You

-Completion of a PhD with a focus on peptide chemistry or a related area.

-An emerging profile in research in the discipline area.

-Skilled in microwave-assisted solid-phase peptide synthesis of disulfide-rich peptides.

-Skilled in folding and purification of disulfide-rich peptides, especially reversed-phase HPLC.

-Experience with development of peptide structure-function relationships.

-Experience with handling and HPLC fractionation of animal venoms.

-Skilled in culture of stable mammalian cell lines.

-Skilled in automated patch-clamp electrophysiology.

-Experience with the Sophion QPatch 16X system is highly desirable.

-Deep knowledge of the structure and function of voltage-gated sodium channels.

-Experience with use of NMR spectroscopy for determining peptide 3D structure.

-Evidence of publications in reputed refereed journals and presentations at peptide conferences.

-A commitment to participating in a diverse, equitable, inclusive, and safe research laboratory environment.

四、申请方式

所有申请人必须上传以下文件，以便您的申请被考虑:

-简历

-求职信

-对“关于您”部分的回复

申请截止日期为2023年11月30日星期四美国东部标准时间晚上11点(R-32260)

All applicants must upload the following documents in order for your application to be considered:

-Resume

-Cover letter

-Responses to the ‘About You’ section

Applications close Thursday 30 November 2023 at 11.00pm AEST (R-32260)

Email:info@zhengzicn.com